| 1. | The molecular regulating mechanisms of intestinal epithelial tight junctions response to pathogenic bacteria
致病菌调控肠道上皮紧密连接的分子机制研究 |
| 2. | Objective the blood - brain barrier ( bbb ) is formed by the complex tight junctions between the endothelial cells of the brain capillaries
背景及目的新生儿细菌性脑膜炎是中枢神经系统最严重的疾病之一，大肠杆菌( escherichiacoli ， e |
| 3. | Zo - 2 is localized in the cytoplasmic plaque domain of tight junction . zo - 2 interacts with the integral membrane proteins via its first pdz domain or guk . domain
Zo 2位于紧密连接处的质膜内表面，一方面与构成紧密连接的跨膜蛋白相互作用，另一方面与细胞骨架发生联系。 |
| 4. | Therefore zo - 2 established a linker between tight junction and cytoskeleton . zo - 2 may regulate the formation or function of tight junction and contact between tight junction and cytoskeleton
因此zo 2的生物学作用可能参与紧密连接形成和功能调节，经细胞骨架而影响细胞的形态和运动。 |
| 5. | Pias1 , a protein that was also located in test ' s specifically was got pdz domain protein tight junction protein 2 and pcg ( polycomb group ) family ring1 and polycomb 2 were included
3kbp （ kyotbindingpotcin ）功能的研究： kbp是我们通过酵母双杂交获得的与kyo ’ fz相互作用的一种新分子。 |
| 6. | Using yeast two - hybrid system with lim domain protein kyotl as a bait , we have isolated an alternatively spliced form of human tight junction protein 2 - - - - - - zo - 2 - i3 . the tight junction ( or zonula occludens ) is the most apical junction between neighbouring epithelial cells or endothelial cells
53为深入研究kyoth在notch rbpjk途径中的可能作用及其作用机制，本实验室以kyoth为诱饵蛋白通过酵母双杂交得到人类紧密连接蛋白zoe 。 |
| 7. | Results the major morphologic changes were as follows : histologically , alveolar inflammation and interstitial fibrosis were observed . electron microscopic findings were : 1 . alveolar type i cells were degenerated 、 broken - down and desquamated , endothelial cells were swelled , with inter cellular tight junction shortened , alveolar type ii cells hyperplastic , basement membrane thinned and deformed ; 2 . alveolar macrophages and interstitial macrophages were hyperplastic ; 3 . mast cells were infiltrated and degranulated ; 4 . electron - dense deposits were present at alveolar wall ; 5 . myofibroblasts 、 fibroblasts 、 collagen and basement membrane like material were hyperplastic
电镜观察可见： ( 1 ) i型肺泡上皮细胞变性、崩解和脱落，内皮细胞肿胀，细胞间紧密连接短小， ii型肺泡上皮细胞增生，基底膜变薄和破坏； ( 2 )肺泡巨噬细胞、间质巨噬细胞增多； ( 3 )肥大细胞浸润并见脱颗粒现象； ( 4 )肺泡壁电子致密物沉积； ( 5 )肌纤维母细胞、纤维母细胞、胶原原纤维及基底膜样物质增生。 |
